VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment

Calcific aortic valve disease (CAVD) is a progressive inflammatory disorder characterized by extracellular matrix remodeling and valvular interstitial cells (VIC) osteodifferentiation leading to valve leaflets calcification and impairment movement. Runx2, the master transcription factor involved in...

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Detalles Bibliográficos
Autores principales: Voicu, Geanina, Rebleanu, Daniela, Mocanu, Cristina Ana, Tanko, Gabriela, Droc, Ionel, Uritu, Cristina Mariana, Pinteala, Mariana, Manduteanu, Ileana, Simionescu, Maya, Calin, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998716/
https://www.ncbi.nlm.nih.gov/pubmed/35409184
http://dx.doi.org/10.3390/ijms23073824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998716/
https://www.ncbi.nlm.nih.gov/pubmed/35409184
http://dx.doi.org/10.3390/ijms23073824

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