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L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis

Macrophage adhesion and stretching have been shown to induce interleukin (IL)-1β production, but the mechanism of this mechanotransduction remains unclear. Here we specify the molecular link between mechanical tension on tissue-resident macrophages and activation of the NLRP3 inflammasome, which gov...

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Detalles Bibliográficos
Autores principales:	Joshi, Hemant, Almgren-Bell, Alison, Anaya, Edgar P., Todd, Elizabeth M., Van Dyken, Steven J., Seth, Anushree, McIntire, Katherine M., Singamaneni, Srikanth, Sutterwala, Fayyaz, Morley, Sharon C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998782/ https://www.ncbi.nlm.nih.gov/pubmed/35294888 http://dx.doi.org/10.1016/j.celrep.2022.110507

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