Functional Characterization of the Solute Carrier LAT-1 (SLC7A5/SLC2A3) in Human Brain Capillary Endothelial Cells with Rapid UPLC-MS/MS Quantification of Intracellular Isotopically Labelled L-Leucine

The solute carrier L-type amino acid transporter 1 (LAT-1/SLC7A5) is a viable target for drug delivery to the central nervous system (CNS) and tumors due to its high abundance at the blood–brain barrier and in tumor tissue. LAT-1 is only localized on the cell surface as a heterodimer with CD98, whic...

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Detalles Bibliográficos
Autores principales: Bay, Cindy, Bajraktari-Sylejmani, Gzona, Haefeli, Walter E., Burhenne, Jürgen, Weiss, Johanna, Sauter, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998838/
https://www.ncbi.nlm.nih.gov/pubmed/35408997
http://dx.doi.org/10.3390/ijms23073637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998838/
https://www.ncbi.nlm.nih.gov/pubmed/35408997
http://dx.doi.org/10.3390/ijms23073637

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