Molecular Lego of Human Cytochrome P450: The Key Role of Heme Domain Flexibility for the Activity of the Chimeric Proteins

The cytochrome P450 superfamily are heme-thiolate enzymes able to carry out monooxygenase reactions. Several studies have demonstrated the feasibility of using a soluble bacterial reductase from Bacillus megaterium, BMR, as an artificial electron transfer partner fused to the human P450 domain in a...

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Detalles Bibliográficos
Autores principales: Catucci, Gianluca, Ciaramella, Alberto, Di Nardo, Giovanna, Zhang, Chao, Castrignanò, Silvia, Gilardi, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998974/
https://www.ncbi.nlm.nih.gov/pubmed/35408976
http://dx.doi.org/10.3390/ijms23073618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998974/
https://www.ncbi.nlm.nih.gov/pubmed/35408976
http://dx.doi.org/10.3390/ijms23073618

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