Toward a Treatment of Cancer: Design and In Vitro/In Vivo Evaluation of Uncharged Pyrazoline Derivatives as a Series of Novel SHP2 Inhibitors

Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene, which is involved in the RAS/MAPK cell signaling transduction process. SHP2 has been shown to contribute to the progression of various cancers and i...

Descripción completa

Detalles Bibliográficos
Autores principales: Dai, Jiajia, Zhang, Yiting, Gao, Yanan, Bai, Xiaoyi, Liu, Fang, Li, Shuo, Yu, Yanyan, Hu, Wenpeng, Shi, Ting, Shi, Dayong, Li, Xiangqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998978/
https://www.ncbi.nlm.nih.gov/pubmed/35408869
http://dx.doi.org/10.3390/ijms23073497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998978/
https://www.ncbi.nlm.nih.gov/pubmed/35408869
http://dx.doi.org/10.3390/ijms23073497

Ejemplares similares