Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice

Wwox-deficient human cells show elevated homologous recombination, leading to resistance to killing by double-strand break-inducing agents. Human Wwox binds to the Brca1 981-PPLF-984 Wwox-binding motif, likely blocking the pChk2 phosphorylation site at Brca1-S988. This phosphorylation site is conser...

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Detalles Bibliográficos
Autores principales: Park, Dongju, Gharghabi, Mehdi, Reczek, Colleen R., Plow, Rebecca, Yungvirt, Charles, Aldaz, C. Marcelo, Huebner, Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999063/
https://www.ncbi.nlm.nih.gov/pubmed/35409089
http://dx.doi.org/10.3390/ijms23073729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999063/
https://www.ncbi.nlm.nih.gov/pubmed/35409089
http://dx.doi.org/10.3390/ijms23073729

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