Cargando…
Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice
Wwox-deficient human cells show elevated homologous recombination, leading to resistance to killing by double-strand break-inducing agents. Human Wwox binds to the Brca1 981-PPLF-984 Wwox-binding motif, likely blocking the pChk2 phosphorylation site at Brca1-S988. This phosphorylation site is conser...
Autores principales: | Park, Dongju, Gharghabi, Mehdi, Reczek, Colleen R., Plow, Rebecca, Yungvirt, Charles, Aldaz, C. Marcelo, Huebner, Kay |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999063/ https://www.ncbi.nlm.nih.gov/pubmed/35409089 http://dx.doi.org/10.3390/ijms23073729 |
Ejemplares similares
-
BRCA1-CtIP interaction in the repair of DNA double-strand breaks
por: Aparicio, Tomas, et al.
Publicado: (2016) -
The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression
por: Reczek, Colleen R., et al.
Publicado: (2013) -
Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition
por: Coquelle, Nicolas, et al.
Publicado: (2011) -
CtIP-mediated resection is essential for viability and can operate independently of BRCA1
por: Polato, Federica, et al.
Publicado: (2014) -
The DNA resection protein CtIP promotes mammary tumorigenesis
por: Reczek, Colleen R., et al.
Publicado: (2016)