Hybrid Pharmacophore- and Structure-Based Virtual Screening Pipeline to Identify Novel EGFR Inhibitors That Suppress Non-Small Cell Lung Cancer Cell Growth

Dysregulated epidermal growth factor receptor (EGFR) expression is frequently observed in non-small cell lung cancer (NSCLC) growth and metastasis. Despite recent successes in the development of tyrosine kinase inhibitors (TKIs), inevitable resistance to TKIs has led to urgent calls for novel EGFR i...

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Detalles Bibliográficos
Autores principales: Weng, Chia-Wei, Wei, Chi-Hsuan, Tsai, Jeng-Yuan, Lai, Yi-Hua, Chang, Gee-Chen, Chen, Jeremy J. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999148/
https://www.ncbi.nlm.nih.gov/pubmed/35408854
http://dx.doi.org/10.3390/ijms23073487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999148/
https://www.ncbi.nlm.nih.gov/pubmed/35408854
http://dx.doi.org/10.3390/ijms23073487

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