Microfluidic-Based Cationic Cholesterol Lipid siRNA Delivery Nanosystem: Highly Efficient In Vitro Gene Silencing and the Intracellular Behavior

Safe and efficient delivery of small interfering RNA (siRNA) is essential to gene therapy towards intervention of genetic diseases. Herein, we developed a novel cationic cholesterol lipid derivative (CEL) in which cholesterol hydrophobic skeleton was connected to L-lysine cationic headgroup via a he...

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Detalles Bibliográficos
Autores principales: Zhu, Zhaoyuan, Zhang, Li, Sheng, Ruilong, Chen, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999516/
https://www.ncbi.nlm.nih.gov/pubmed/35409359
http://dx.doi.org/10.3390/ijms23073999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999516/
https://www.ncbi.nlm.nih.gov/pubmed/35409359
http://dx.doi.org/10.3390/ijms23073999

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