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Mechanism of Action of an Environmentally Relevant Organochlorine Mixture in Repressing Steroid Hormone Biosynthesis in Leydig Cells †

Within Leydig cells, steroidogenesis is induced by the pituitary luteinizing hormone (LH). The binding of LH to its receptor increases cAMP production, which then activates the expression of genes involved in testosterone biosynthesis. One of these genes codes for the steroidogenic acute regulatory...

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Detalles Bibliográficos
Autores principales: Enangue Njembele, Annick N., Demmouche, Zoheir B., Bailey, Janice L., Tremblay, Jacques J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999779/
https://www.ncbi.nlm.nih.gov/pubmed/35409357
http://dx.doi.org/10.3390/ijms23073997