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Aggregation chimeras provide evidence of in vivo intercellular correction in ovine CLN6 neuronal ceroid lipofuscinosis (Batten disease)

The neuronal ceroid lipofuscinoses (NCLs; Batten disease) are fatal, mainly childhood, inherited neurodegenerative lysosomal storage diseases. Sheep affected with a CLN6 form display progressive regionally defined glial activation and subsequent neurodegeneration, indicating that neuroinflammation m...

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Detalles Bibliográficos
Autores principales:	Barry, Lucy Anne, Kay, Graham William, Mitchell, Nadia Lesley, Murray, Samantha Jane, Jay, Nigel P., Palmer, David Norris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000108/ https://www.ncbi.nlm.nih.gov/pubmed/35404973 http://dx.doi.org/10.1371/journal.pone.0261544

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