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Development of Bicyclo[3.1.0]hexane-Based A(3) Receptor Ligands: Closing the Gaps in the Structure–Affinity Relationships

The adenosine A(3) receptor is a promising target for treating and diagnosing inflammation and cancer. In this paper, a series of bicyclo[3.1.0]hexane-based nucleosides was synthesized and evaluated for their P1 receptor affinities in radioligand binding studies. The study focused on modifications a...

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Detalles Bibliográficos
Autores principales:	Lemmerhirt, Jan Phillip, Isaak, Andreas, Liu, Rongfang, Kock, Max, Daniliuc, Constantin G., Jacobson, Kenneth A., Heitman, Laura H., Junker, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000336/ https://www.ncbi.nlm.nih.gov/pubmed/35408685 http://dx.doi.org/10.3390/molecules27072283

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