Enhancement of the Anti-Inflammatory Activity of NSAIDs by Their Conjugation with 3,4,5-Trimethoxybenzyl Alcohol

The synthesis of derivatives of three nonspecific COX-1 and COX-2 inhibitors, ibuprofen, ketoprofen, naproxen is presented. These acids were connected via an amide bond with an amino acid (L-proline, L-tyrosine, and beta-alanine) used as a linker. The amino acid carboxylic group was esterified with...

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Detalles Bibliográficos
Autores principales: Tziona, Paraskevi, Theodosis-Nobelos, Panagiotis, Papagiouvannis, Georgios, Petrou, Anthi, Drouza, Chryssoula, Rekka, Eleni A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000480/
https://www.ncbi.nlm.nih.gov/pubmed/35408503
http://dx.doi.org/10.3390/molecules27072104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000480/
https://www.ncbi.nlm.nih.gov/pubmed/35408503
http://dx.doi.org/10.3390/molecules27072104

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