Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers

Some new pyrimidine derivatives comprising arylsulfonylhydrazino, ethoxycarbonylhydrazino, thiocarbamoylhydrazino and substituted hydrazone and thiosemicarbazide functionalities were prepared from Biginelli-derived pyrimidine precursors. Heterocyclic ring systems such as pyrazole, pyrazolidinedione,...

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Detalles Bibliográficos
Autores principales: Farghaly, Ahmed M., Rizk, Ola H., Darwish, Inas, Hamza, Manal, Altowyan, Mezna Saleh, Barakat, Assem, Teleb, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000669/
https://www.ncbi.nlm.nih.gov/pubmed/35408650
http://dx.doi.org/10.3390/molecules27072240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000669/
https://www.ncbi.nlm.nih.gov/pubmed/35408650
http://dx.doi.org/10.3390/molecules27072240

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