Cargando…

Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers

Some new pyrimidine derivatives comprising arylsulfonylhydrazino, ethoxycarbonylhydrazino, thiocarbamoylhydrazino and substituted hydrazone and thiosemicarbazide functionalities were prepared from Biginelli-derived pyrimidine precursors. Heterocyclic ring systems such as pyrazole, pyrazolidinedione,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farghaly, Ahmed M., Rizk, Ola H., Darwish, Inas, Hamza, Manal, Altowyan, Mezna Saleh, Barakat, Assem, Teleb, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000669/ https://www.ncbi.nlm.nih.gov/pubmed/35408650 http://dx.doi.org/10.3390/molecules27072240

Ejemplares similares

Biginelli Reaction Mediated Synthesis of Antimicrobial Pyrimidine Derivatives and Their Therapeutic Properties
por: Marinescu, Maria
Publicado: (2021)

Spiroindolone Analogues as Potential Hypoglycemic with Dual Inhibitory Activity on α-Amylase and α-Glucosidase
por: Altowyan, Mezna Saleh, et al.
Publicado: (2019)

Spiroindolone analogues bearing benzofuran moiety as a selective cyclooxygenase COX-1 with TNF-α and IL-6 inhibitors
por: Altowyan, Mezna Saleh, et al.
Publicado: (2020)

Ethyl 5-methyl-7-phenyl-1,2,4-triazolo[4,3-a]pyrimidine-6-carboxylate
por: AboulWafa, Omaima M., et al.
Publicado: (2014)

Ultrasound-assisted synthesis of pyrimidines and their fused derivatives: A review
por: Mittersteiner, Mateus, et al.
Publicado: (2021)

Deciphering the Impact of Mutations on the Binding Efficacy of SARS-CoV-2 Omicron and Delta Variants With Human ACE2 Receptor
por: Khan, Alamgir, et al.
Publicado: (2022)

Vibrational spectral analysis, XRD-structure, computation, exo⇔endo isomerization and non-linear optical crystal of 5-((5-chloro-1H-indol-2-yl)methylene)-1,3-diethyl-2-thioxodihy-dropyrimidine-4,6 (1H,5H)-dione
por: Altowyan, Mezna Saleh, et al.
Publicado: (2019)

Enhancing the Anticancer Potential of Targeting Tumor-Associated Metalloenzymes via VEGFR Inhibition by New Triazolo[4,3-a]pyrimidinone Acyclo C-Nucleosides Multitarget Agents
por: Abd Al Moaty, Mohamed Nabil, et al.
Publicado: (2022)

Synthesis, Characterization, and Cytotoxicity of New Spirooxindoles Engrafted Furan Structural Motif as a Potential Anticancer Agent
por: Altowyan, Mezna Saleh, et al.
Publicado: (2022)

Synthesis and Structure Elucidation of Novel Spirooxindole Linked to Ferrocene and Triazole Systems via [3 + 2] Cycloaddition Reaction
por: Altowyan, Mezna Saleh, et al.
Publicado: (2022)

Palladium-Catalyzed Intramolecular Cross-Dehydrogenative Coupling: Synthesis of Fused Imidazo[1,2-a]pyrimidines and Pyrazolo[1,5-a]pyrimidines
por: Reddy Kotla, Siva K., et al.
Publicado: (2017)

A Review on Fused Pyrimidine Systems as EGFR Inhibitors and Their Structure–Activity Relationship
por: Yadav, Tanuja T., et al.
Publicado: (2022)

Synthesis, X-ray Diffraction, Thermogravimetric and DFT Analyses of Pyrimidine Derivatives
por: Barakat, Assem, et al.
Publicado: (2014)

A New Pt(II) Complex with Anionic s-Triazine Based NNO-Donor Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis and DFT Studies
por: Altowyan, Mezna Saleh, et al.
Publicado: (2022)

Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+2] Cycloaddition Reaction: An MEDT Study of the Mechanism and Selectivity
por: Alshahrani, Saeed, et al.
Publicado: (2023)

Bis[2-(pyrimidin-2-ylamino)pyrimidinium] hexamolybdate
por: Yeh, Chun-Wei, et al.
Publicado: (2007)

2-Phenoxypyrimidine
por: Shah Bakhtiar, Nasir, et al.
Publicado: (2008)

Pyrimidine-2-carboxamide
por: Zhang, Bing-Yu, et al.
Publicado: (2007)

Synthesis of Pyrimidine- and Quinazoline-Fused Benzimidazole-4,7-diones Using Combinatorial Cyclocondensation and Oxidation
por: Kim, Dong Young, et al.
Publicado: (2018)

In vitro selection of small RNA-cleaving deoxyribozymes that cleave pyrimidine–pyrimidine junctions
por: Schlosser, Kenny, et al.
Publicado: (2008)

Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism
por: Harpel, Zander, et al.
Publicado: (2023)

Synthesis of a Novel Unexpected Cu(II)–Thiazolidine Complex—X-ray Structure, Hirshfeld Surface Analysis, and Biological Studies
por: Altowyan, Mezna Saleh, et al.
Publicado: (2022)

Synthesis and Inhibitory Effect of Some Indole‐Pyrimidine Based Hybrid Heterocycles on α‐Glucosidase and α‐Amylase as Potential Hypoglycemic Agents
por: Badria, Farid A., et al.
Publicado: (2019)

Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives
por: Al-Majid, Abdullah M., et al.
Publicado: (2013)

Selective recognition of pyrimidine–pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators
por: Bahr, Matthias, et al.
Publicado: (2008)

2-[3-Methoxy-5-(pyrimidin-2-yl)phenyl]pyrimidine
por: Hu, Jiena, et al.
Publicado: (2013)

Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors
por: Barakat, Assem, et al.
Publicado: (2020)

Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Pyrimidine Derivatives as Potential Calcium Channel Blockers
por: Zohny, Yasser M., et al.
Publicado: (2023)

Pyrimidine salvage in Giardia lamblia
Publicado: (1985)

2,4-Dichloropyrimidine
por: Chen, Yan, et al.
Publicado: (2009)

Synthesis, X-ray Structure, Hirshfeld, DFT and Biological Studies on a Quinazolinone-Nitrate Complex
por: Fathalla, Eman M., et al.
Publicado: (2022)

Androgen Receptor Antagonists and Anti-Prostate Cancer Activities of Some Newly Synthesized Substituted Fused Pyrazolo-, Triazolo- and Thiazolo-Pyrimidine Derivatives
por: Bahashwan, Saleh A., et al.
Publicado: (2014)

Biginelli Reaction Catalyzed by Copper Nanoparticles
por: Dewan, Manika, et al.
Publicado: (2012)

Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine Derivatives
por: Abunada, Nada M., et al.
Publicado: (2008)

Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors
por: Mahgoub, Mohamed Y., et al.
Publicado: (2019)

Metal-Free Construction of Fused Pyrimidines via Consecutive C–C and C–N Bond Formation in Water
por: Sahu, Pramod K., et al.
Publicado: (2018)

An efficient, mild and metal free l-proline catalyzed construction of fused pyrimidines under microwave conditions in water
por: Kaurav, Manvendra S., et al.
Publicado: (2019)

Promising Antidiabetic and Antimicrobial Agents Based on Fused Pyrimidine Derivatives: Molecular Modeling and Biological Evaluation with Histopathological Effect
por: Bassyouni, Fatma, et al.
Publicado: (2021)

Indolizines and pyrrolo[1,2-c]pyrimidines decorated with a pyrimidine and a pyridine unit respectively
por: Popa, Marcel Mirel, et al.
Publicado: (2015)

New Indazol-Pyrimidine-Based Derivatives as Selective Anticancer Agents: Design, Synthesis, and In Silico Studies
por: Al-Tuwaijri, Hanaa M., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_urn4df6p9o25s6j4urpnboeij1