Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis

Germline pathogenic mutations in BReast CAncer (BRCA1) genes are thought to drive normal fallopian tube epithelial (FTE) cell transformation to high-grade serous ovarian cancer. No human models capture the sequence of events for disease initiation and progression. Here, we generate induced pluripote...

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Detalles Bibliográficos
Autores principales: Yucer, Nur, Ahdoot, Rodney, Workman, Michael J., Laperle, Alexander H., Recouvreux, Maria S., Kurowski, Kathleen, Naboulsi, Diana J., Liang, Victoria, Qu, Ying, Plummer, Jasmine T., Gayther, Simon A., Orsulic, Sandra, Karlan, Beth Y., Svendsen, Clive N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000920/
https://www.ncbi.nlm.nih.gov/pubmed/34965417
http://dx.doi.org/10.1016/j.celrep.2021.110146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000920/
https://www.ncbi.nlm.nih.gov/pubmed/34965417
http://dx.doi.org/10.1016/j.celrep.2021.110146

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