Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

Human serine racemase (hSR) catalyses racemisation of L-serine to D-serine, the latter of which is a co-agonist of the NMDA subtype of glutamate receptors that are important in synaptic plasticity, learning and memory. In a ‘closed’ hSR structure containing the allosteric activator ATP, the inhibito...

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Detalles Bibliográficos
Autores principales: Koulouris, Chloe R., Gardiner, Sian E., Harris, Tessa K., Elvers, Karen T., Mark Roe, S., Gillespie, Jason A., Ward, Simon E., Grubisha, Olivera, Nicholls, Robert A., Atack, John R., Bax, Benjamin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001717/
https://www.ncbi.nlm.nih.gov/pubmed/35410329
http://dx.doi.org/10.1038/s42003-022-03264-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001717/
https://www.ncbi.nlm.nih.gov/pubmed/35410329
http://dx.doi.org/10.1038/s42003-022-03264-5

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