The ZZ domain of HERC2 is a receptor of arginylated substrates

The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of HERC2 (HERC2(ZZ)) recognizes a mimetic of the Nt-R cargo degradation signal. NMR titration experiments and mutagenesis resul...

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Detalles Bibliográficos
Autores principales: Tencer, Adam H., Liu, Jiuyang, Zhu, Jing, Burkholder, Nathaniel T., Zhang, Yi, Wu, Wenwen, Strahl, Brian D., Ohta, Tomohiko, Kutateladze, Tatiana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001736/
https://www.ncbi.nlm.nih.gov/pubmed/35411094
http://dx.doi.org/10.1038/s41598-022-10119-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001736/
https://www.ncbi.nlm.nih.gov/pubmed/35411094
http://dx.doi.org/10.1038/s41598-022-10119-w

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