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The ZZ domain of HERC2 is a receptor of arginylated substrates
The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of HERC2 (HERC2(ZZ)) recognizes a mimetic of the Nt-R cargo degradation signal. NMR titration experiments and mutagenesis resul...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001736/ https://www.ncbi.nlm.nih.gov/pubmed/35411094 http://dx.doi.org/10.1038/s41598-022-10119-w |