Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules

BACKGROUND: Extrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and toxicity profiles of new radiopharmaceuticals. Comparative studies between available animal-to-human dosimetry extrapolation methods are missing. We comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Cicone, Francesco, Viertl, David, Denoël, Thibaut, Stabin, Michael G., Prior, John O., Gnesin, Silvano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001797/
https://www.ncbi.nlm.nih.gov/pubmed/35403982
http://dx.doi.org/10.1186/s13550-022-00893-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001797/
https://www.ncbi.nlm.nih.gov/pubmed/35403982
http://dx.doi.org/10.1186/s13550-022-00893-z

Ejemplares similares