A novel prothrombotic role of proprotein convertase subtilisin kexin 9: the generation of procoagulant extracellular vesicles by human mononuclear cells

BACKGROUND: Proprotein convertase subtilisin kexin 9 (PCSK9) is a serin protease synthesized mainly in the liver that binds the receptor of low-density lipoprotein and promotes its degradation in lysosomes. PCSK9 is considered a promising target for the development of new therapies for the treatment...

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Detalles Bibliográficos
Autores principales: Scalise, Valentina, Lombardi, Stefania, Sanguinetti, Chiara, Nieri, Dario, Pedrinelli, Roberto, Celi, Alessandro, Neri, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001820/
https://www.ncbi.nlm.nih.gov/pubmed/35412175
http://dx.doi.org/10.1007/s11033-022-07433-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001820/
https://www.ncbi.nlm.nih.gov/pubmed/35412175
http://dx.doi.org/10.1007/s11033-022-07433-x

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