A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer

The SIRPαFc fusion protein can block the immunosuppressive CD47-SIRPα signal between macrophages and tumor cells as a decoy receptor and has demonstrated its immunotherapeutic efficacy in various tumors. However, its clinical application was limited because of the potential hematologic toxicity. The...

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Detalles Bibliográficos
Autores principales: Liu, Jiayang, Meng, Zhefeng, Xu, Tongyang, Kuerban, Kudelaidi, Wang, Songna, Zhang, Xuyao, Fan, Jiajun, Ju, Dianwen, Tian, Wenzhi, Huang, Xuan, Huang, Xiting, Pan, Danjie, Chen, Huaning, Zhao, Weili, Ye, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002095/
https://www.ncbi.nlm.nih.gov/pubmed/35422796
http://dx.doi.org/10.3389/fimmu.2022.845217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002095/
https://www.ncbi.nlm.nih.gov/pubmed/35422796
http://dx.doi.org/10.3389/fimmu.2022.845217

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