A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to fibrosis. These cells secrete senescence-associated secretory phenotype (SASP) factors that are involved in diverse signaling pathways, influencing kidney fibrosis. Here, we investigated whether our previously...

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Detalles Bibliográficos
Autores principales: Yang, Yi, Mihajlovic, Milos, Valentijn, Floris, Nguyen, Tri Q., Goldschmeding, Roel, Masereeuw, Rosalinde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002109/
https://www.ncbi.nlm.nih.gov/pubmed/35422705
http://dx.doi.org/10.3389/fphar.2022.791612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002109/
https://www.ncbi.nlm.nih.gov/pubmed/35422705
http://dx.doi.org/10.3389/fphar.2022.791612

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