Cargando…

An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin

Aureolysin, a secreted metallopeptidase (MP) from the thermolysin family, functions as a major virulence factor in Staphylococcus aureus. No specific aureolysin inhibitors have yet been described, making this an important target for the development of novel antimicrobial drugs in times of rampant an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mendes, Soraia R., Eckhard, Ulrich, Rodríguez-Banqueri, Arturo, Guevara, Tibisay, Czermak, Peter, Marcos, Enrique, Vilcinskas, Andreas, Gomis-Rüth, F. Xavier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002140/ https://www.ncbi.nlm.nih.gov/pubmed/35465156 http://dx.doi.org/10.1016/j.csbj.2022.01.001

Ejemplares similares

Polymorphism, genetic exchange and intragenic recombination of the aureolysin gene among Staphylococcus aureus strains
por: Sabat, Artur J, et al.
Publicado: (2008)

Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases
por: Guevara, Tibisay, et al.
Publicado: (2020)

Zymogenic latency in an ∼250-million-year-old astacin metallopeptidase
por: Guevara, Tibisay, et al.
Publicado: (2022)

Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy
por: del Amo-Maestro, Laura, et al.
Publicado: (2022)

Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor
por: Guevara, Tibisay, et al.
Publicado: (2019)

De novo design of immunoglobulin-like domains
por: Chidyausiku, Tamuka M., et al.
Publicado: (2022)

Biogeography and Virulence of Staphylococcus aureus
por: Fan, Juan, et al.
Publicado: (2009)

Pathogenicity and virulence of Staphylococcus aureus
por: Cheung, Gordon Y. C., et al.
Publicado: (2021)

Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale
por: Akopova, Olga, et al.
Publicado: (2020)

Synthesis and Characterization of Store-Operated Calcium Entry Inhibitors Active in the Submicromolar Range
por: Le Guilcher, Camille, et al.
Publicado: (2020)

Aureusimines in Staphylococcus aureus Are Not Involved in Virulence
por: Sun, Fei, et al.
Publicado: (2010)

Hydrophobic Rose Bengal Derivatives Exhibit Submicromolar-to-Subnanomolar Activity against Enveloped Viruses
por: Rubekina, Anna A., et al.
Publicado: (2022)

Molecular Basis of Virulence in Staphylococcus aureus Mastitis
por: Le Maréchal, Caroline, et al.
Publicado: (2011)

The Staphylococcus aureus RNome and Its Commitment to Virulence
por: Felden, Brice, et al.
Publicado: (2011)

2602. Genetic Basis of Staphylococcus aureus Virulence
por: Adams, Edward W, et al.
Publicado: (2019)

Submicromolar levels of calcium control the balance of beating between the two flagella in demembranated models of Chlamydomonas
Publicado: (1984)

Novel Cytokinin Derivatives Do Not Show Negative Effects on Root Growth and Proliferation in Submicromolar Range
por: Podlešáková, Kateřina, et al.
Publicado: (2012)

Double Quantum Coherence ESR at Q-Band Enhances the Sensitivity of Distance Measurements at Submicromolar Concentrations
por: Mandato, Alysia, et al.
Publicado: (2023)

Repositioning small molecule drugs as allosteric inhibitors of the BFT‐3 toxin from enterotoxigenic Bacteroides fragilis
por: Jimenez‐Alesanco, Ana, et al.
Publicado: (2022)

Regulation of Staphylococcus aureus Virulence and Application of Nanotherapeutics to Eradicate S. aureus Infection
por: Arunachalam, Kannappan, et al.
Publicado: (2023)

New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi
por: Pedron, Julien, et al.
Publicado: (2020)

NMR Discrimination of d- and l-α-Amino Acids at Submicromolar Concentration via Parahydrogen-Induced Hyperpolarization
por: Dreisewerd, Lennart, et al.
Publicado: (2023)

On the evolution of virulence during Staphylococcus aureus nasal carriage
por: Young, Bernadette C., et al.
Publicado: (2012)

Effect of Photodynamic Therapy on the Virulence Factors of Staphylococcus aureus
por: Bartolomeu, Maria, et al.
Publicado: (2016)

Loratadine inhibits Staphylococcus aureus virulence and biofilm formation
por: Zheng, Jinxin, et al.
Publicado: (2022)

Virulence Gene Expression of Staphylococcus aureus in Human Skin
por: Cruz, Ana Rita, et al.
Publicado: (2021)

Expression of Staphylococcus aureus Virulence Factors in Atopic Dermatitis
por: Poh, Si En, et al.
Publicado: (2022)

Distinctly Different Morphologies of Bimetallic Au-Ag Nanostructures and Their Application in Submicromolar SERS-Detection of Free Base Porphyrin
por: Vilímová, Iveta, et al.
Publicado: (2021)

Identification of Secreted Exoproteome Fingerprints of Highly-Virulent and Non-Virulent Staphylococcus aureus Strains
por: Bonar, Emilia, et al.
Publicado: (2016)

Igniting the Fire: Staphylococcus aureus Virulence Factors in the Pathogenesis of Sepsis
por: Powers, Michael E., et al.
Publicado: (2014)

Counter inhibition between leukotoxins attenuates Staphylococcus aureus virulence
por: Yoong, Pauline, et al.
Publicado: (2015)

Genetic requirements for Staphylococcus aureus nitric oxide resistance and virulence
por: Grosser, Melinda R., et al.
Publicado: (2018)

Staphylococcus aureus Responds to the Central Metabolite Pyruvate To Regulate Virulence
por: Harper, Lamia, et al.
Publicado: (2018)

Effect of nicotine on Staphylococcus aureus biofilm formation and virulence factors
por: Shi, Le, et al.
Publicado: (2019)

Citral modulates virulence factors in methicillin-resistant Staphylococcus aureus
por: Oliveira, Hellen Braga Martins, et al.
Publicado: (2021)

Global Transcriptomic Response of Staphylococcus aureus to Virulent Bacteriophage Infection
por: Kuptsov, Nikita, et al.
Publicado: (2022)

Virulence Determinants in Staphylococcus aureus Clones Causing Osteomyelitis in Italy
por: Pimentel de Araujo, Fernanda, et al.
Publicado: (2022)

PurN Is Involved in Antibiotic Tolerance and Virulence in Staphylococcus aureus
por: Peng, Qi, et al.
Publicado: (2022)

Editorial: “Omics”- revolution in elucidating the virulence and resistance in Staphylococcus aureus
por: Nurjadi, Dennis, et al.
Publicado: (2023)

Targeting host deoxycytidine kinase attenuates Staphylococcus aureus virulence
por: Winstel, Volker, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_f1k4si3jp4ks36m1vkfh01r27r