Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome

Dravet syndrome is a neurodevelopmental disorder characterized by epilepsy, intellectual disability, and sudden death due to pathogenic variants in SCN1A with loss of function of the sodium channel subunit Nav1.1. Nav1.1-expressing parvalbumin GABAergic interneurons (PV-INs) from young Scn1a(+/−) mi...

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Detalles Bibliográficos
Autores principales: Kaneko, Keisuke, Currin, Christopher B., Goff, Kevin M., Wengert, Eric R., Somarowthu, Ala, Vogels, Tim P., Goldberg, Ethan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003081/
https://www.ncbi.nlm.nih.gov/pubmed/35354025
http://dx.doi.org/10.1016/j.celrep.2022.110580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003081/
https://www.ncbi.nlm.nih.gov/pubmed/35354025
http://dx.doi.org/10.1016/j.celrep.2022.110580

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