Hit Expansion of a Noncovalent SARS-CoV-2 Main Protease Inhibitor

[Image: see text] Inhibition of the SARS-CoV-2 main protease (M(pro)) is a major focus of drug discovery efforts against COVID-19. Here we report a hit expansion of non-covalent inhibitors of M(pro). Starting from a recently discovered scaffold (The COVID Moonshot Consortium. Open Science Discovery...

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Detalles Bibliográficos
Autores principales: Glaser, Jens, Sedova, Ada, Galanie, Stephanie, Kneller, Daniel W., Davidson, Russell B., Maradzike, Elvis, Del Galdo, Sara, Labbé, Audrey, Hsu, Darren J., Agarwal, Rupesh, Bykov, Dmytro, Tharrington, Arnold, Parks, Jerry M., Smith, Dayle M. A., Daidone, Isabella, Coates, Leighton, Kovalevsky, Andrey, Smith, Jeremy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003389/
https://www.ncbi.nlm.nih.gov/pubmed/35434531
http://dx.doi.org/10.1021/acsptsci.2c00026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003389/
https://www.ncbi.nlm.nih.gov/pubmed/35434531
http://dx.doi.org/10.1021/acsptsci.2c00026

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