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Single-cell analysis of p53 transitional dynamics unravels stimulus- and cell type-dependent signaling output motifs

BACKGROUND: To understand functional changes of complex biological networks, mathematical modeling of network topologies provides a quantitative measure of the way biological systems adapt to external stimuli. However, systemic network topology-based analysis often generates conflicting evidence dep...

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Detalles Bibliográficos
Autores principales: Xie, Jun, Zhang, Lichun, Liu, Bodong, Liang, Xiao, Shi, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004066/
https://www.ncbi.nlm.nih.gov/pubmed/35410287
http://dx.doi.org/10.1186/s12915-022-01290-7