Neural network modeling of differential binding between wild-type and mutant CTCF reveals putative binding preferences for zinc fingers 1–2

BACKGROUND: Many transcription factors (TFs), such as multi zinc-finger (ZF) TFs, have multiple DNA binding domains (DBDs), and deciphering the DNA binding motifs of individual DBDs is a major challenge. One example of such a TF is CCCTC-binding factor (CTCF), a TF with eleven ZFs that plays a varie...

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Detalles Bibliográficos
Autores principales: Kaplow, Irene M., Banerjee, Abhimanyu, Foo, Chuan Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004084/
https://www.ncbi.nlm.nih.gov/pubmed/35410161
http://dx.doi.org/10.1186/s12864-022-08486-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004084/
https://www.ncbi.nlm.nih.gov/pubmed/35410161
http://dx.doi.org/10.1186/s12864-022-08486-9

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