Carbonic anhydrase IX-targeted H-APBC nanosystem combined with phototherapy facilitates the efficacy of PI3K/mTOR inhibitor and resists HIF-1α-dependent tumor hypoxia adaptation

BACKGROUND: Non-redundant properties such as hypoxia and acidosis promote tumor metabolic adaptation and limit anti-cancer therapies. The key to the adaptation of tumor cells to hypoxia is the transcriptional and stable expression of hypoxia-inducible factor-1 alpha (HIF-1α). The phosphorylation-act...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Hu, Xiaochun, Feng, Lei, Lin, Yun, Liang, Shujing, Zhu, Zhounan, Shi, Shuo, Dong, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004111/
https://www.ncbi.nlm.nih.gov/pubmed/35413842
http://dx.doi.org/10.1186/s12951-022-01394-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004111/
https://www.ncbi.nlm.nih.gov/pubmed/35413842
http://dx.doi.org/10.1186/s12951-022-01394-w

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