Double-activation of mitochondrial permeability transition pore opening via calcium overload and reactive oxygen species for cancer therapy

BACKGROUND: Calcium ions (Ca(2+)) participates in various intracellular signal cascades and especially plays a key role in pathways relevant to cancer cells. Mitochondrial metabolism stimulated by calcium overload can trigger the opening of the mitochondrial permeability transition pore (MPTP), whic...

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Detalles Bibliográficos
Autores principales: Zhou, Ying, Jing, Shisong, Liu, Sainan, Shen, Xizhong, Cai, Lihan, Zhu, Changfeng, Zhao, Yicheng, Pang, Maolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004178/
https://www.ncbi.nlm.nih.gov/pubmed/35413984
http://dx.doi.org/10.1186/s12951-022-01392-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004178/
https://www.ncbi.nlm.nih.gov/pubmed/35413984
http://dx.doi.org/10.1186/s12951-022-01392-y

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