Development of small cyclic peptides targeting the CK2α/β interface

In this work, an iterative cycle of enzymatic assays, X-ray crystallography, molecular modelling and cellular assays were used to develop a functionalisable chemical probe for the CK2α/β PPI. The lead peptide, P8C9, successfully binds to CK2α at the PPI site, is easily synthesisable and functionalis...

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Detalles Bibliográficos
Autores principales: Atkinson, Eleanor L., Iegre, Jessica, D’Amore, Claudio, Brear, Paul, Salvi, Mauro, Hyvönen, Marko, Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004346/
https://www.ncbi.nlm.nih.gov/pubmed/35343996
http://dx.doi.org/10.1039/d2cc00707j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004346/
https://www.ncbi.nlm.nih.gov/pubmed/35343996
http://dx.doi.org/10.1039/d2cc00707j

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