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Canalization of the Polygenic Risk for Common Diseases and Traits in the UK Biobank Cohort

Since organisms develop and thrive in the face of constant perturbations due to environmental and genetic variation, species may evolve resilient genetic architectures. We sought evidence for this process, known as canalization, through a comparison of the prevalence of phenotypes as a function of t...

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Detalles Bibliográficos
Autores principales: Nagpal, Sini, Tandon, Raghav, Gibson, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004416/
https://www.ncbi.nlm.nih.gov/pubmed/35275999
http://dx.doi.org/10.1093/molbev/msac053