Cargando…

Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3

BACKGROUND: Delivery of viral vectors as gene therapies to treat neurodegenerative diseases has been hampered by the inability to penetrate the blood brain barrier (BBB) and invasive or non-targeted delivery options prone to inducing immune responses. MR guided focused ultrasound (MR-g-FUS) and micr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trinh, Dennison, Nash, Joanne, Goertz, David, Hynynen, Kullervo, Bulner, Sharsi, Iqbal, Umar, Keenan, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004516/ https://www.ncbi.nlm.nih.gov/pubmed/35393905 http://dx.doi.org/10.1080/10717544.2022.2035855

Ejemplares similares

Neutrophil recruitment and leukocyte response following focused ultrasound and microbubble mediated blood-brain barrier treatments
por: Poon, Charissa, et al.
Publicado: (2021)

Neutrophil Recruitment and Leukocyte Response Following Focused Ultrasound and Microbubble Mediated Blood-Brain Barrier Treatments
por: Poon, Charissa, et al.
Publicado: (2022)

Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose
por: McMahon, Dallan, et al.
Publicado: (2017)

Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure
por: McMahon, Dallan, et al.
Publicado: (2020)

Focused Ultrasound and Microbubbles-Mediated Drug Delivery to Brain Tumor
por: Wu, Sheng-Kai, et al.
Publicado: (2020)

Reply to Kovacs et al.: Concerning acute inflammatory response following focused ultrasound and microbubbles in the brain
por: McMahon, Dallan, et al.
Publicado: (2018)

Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain
por: McMahon, Dallan, et al.
Publicado: (2020)

Antitumor Effects of Combining Docetaxel (Taxotere) with the Antivascular Action of Ultrasound Stimulated Microbubbles
por: Goertz, David E., et al.
Publicado: (2012)

A PVDF Receiver for Acoustic Monitoring of Microbubble-Mediated Ultrasound Brain Therapy
por: Lin, Yi, et al.
Publicado: (2023)

Focused Ultrasound Hyperthermia Mediated Drug Delivery Using Thermosensitive Liposomes and Visualized With in vivo Two-Photon Microscopy
por: Santos, Marc A., et al.
Publicado: (2017)

Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening
por: Jones, Ryan M., et al.
Publicado: (2018)

Angiogenic response of rat hippocampal vasculature to focused ultrasound-mediated increases in blood-brain barrier permeability
por: McMahon, Dallan, et al.
Publicado: (2018)

Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome
por: McMahon, Dallan, et al.
Publicado: (2017)

High-Intensity Focused Ultrasound (HIFU) for Dissolution of Clots in a Rabbit Model of Embolic Stroke
por: Burgess, Alison, et al.
Publicado: (2012)

Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability
por: Mooney, Skyler J., et al.
Publicado: (2016)

Therapeutic effects of focused ultrasound-mediated blood-brain barrier opening in a mouse model of Alzheimer’s disease
por: Burgess, Alison, et al.
Publicado: (2015)

Novel fractionated ultrashort thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs
por: Santos, Marc A., et al.
Publicado: (2020)

Ultrafast three-dimensional microbubble imaging in vivo predicts tissue damage volume distributions during nonthermal brain ablation
por: Jones, Ryan M., et al.
Publicado: (2020)

Microbubble protein delivery for Parkinson’s
por: Keenan, James, et al.
Publicado: (2015)

Driving Circuitry for Focused Ultrasound Noninvasive Surgery and Drug Delivery Applications
por: El-Desouki, Munir M., et al.
Publicado: (2011)

Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery
por: Weber-Adrian, Danielle, et al.
Publicado: (2021)

Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging
por: O'Reilly, Meaghan Anne, et al.
Publicado: (2017)

Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier
por: Burgess, Alison, et al.
Publicado: (2011)

Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats
por: Jalali, Shahrzad, et al.
Publicado: (2010)

Comparison of computer simulations and clinical treatment results of magnetic resonance‐guided focused ultrasound surgery (MRgFUS) of uterine fibroids
por: Hyvärinen, Mikko, et al.
Publicado: (2022)

Targeted and Reversible Blood-Retinal Barrier Disruption via Focused Ultrasound and Microbubbles
por: Park, Juyoung, et al.
Publicado: (2012)

Vasculotide restores the blood-brain barrier after focused ultrasound-induced permeability in a mouse model of Alzheimer's disease
por: Lynch, Madelaine, et al.
Publicado: (2021)

The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites
por: Kofoed, Rikke Hahn, et al.
Publicado: (2022)

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
por: Lipsman, Nir, et al.
Publicado: (2018)

Anesthetic‐loaded nanodroplets with focused ultrasound reduces agitation in Alzheimer's mice
por: Gouveia, Flavia Venetucci, et al.
Publicado: (2023)

MR-guided Focused Ultrasound Facilitates Sonodynamic Therapy with 5-Aminolevulinic Acid in a Rat Glioma Model
por: Wu, Sheng-Kai, et al.
Publicado: (2019)

Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening
por: Wu, Sheng-Kai, et al.
Publicado: (2017)

ET-04 Enhancing drug delivery with MRI-guided focused ultrasound for diffuse intrinsic pontine glioma model
por: Ishida, Joji, et al.
Publicado: (2020)

Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis
por: Kofoed, Rikke Hahn, et al.
Publicado: (2021)

Cavitation Feedback Control of Focused Ultrasound Blood-Brain Barrier Opening for Drug Delivery in Patients with Parkinson’s Disease
por: Huang, Yuexi, et al.
Publicado: (2022)

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
por: Abrahao, Agessandro, et al.
Publicado: (2019)

Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening
por: Tsai, Hong-Chieh, et al.
Publicado: (2018)

Ultrasound‐Triggered Delivery of Iproplatin from Microbubble‐Conjugated Liposomes
por: Browning, Richard, et al.
Publicado: (2021)

A computerized tablet system for evaluating treatment of essential tremor by magnetic resonance guided focused ultrasound
por: Tam, Fred, et al.
Publicado: (2017)

Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study
por: Mainprize, Todd, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_aah8iq8109qfhttdrfrs86snf4