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MD Simulations Revealing Special Activation Mechanism of Cannabinoid Receptor 1

Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor (GPCR) that is gaining much interest for its regulating role in the central nervous system and its value as a drug target. Structures of CB1 in inactive and active states have revealed conformational change details that are not common in o...

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Detalles Bibliográficos
Autores principales: Wu, Yiran, Li, Xuanxuan, Hua, Tian, Liu, Zhi-Jie, Liu, Haiguang, Zhao, Suwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004671/
https://www.ncbi.nlm.nih.gov/pubmed/35425811
http://dx.doi.org/10.3389/fmolb.2022.860035