Targeted Elimination of bla(NDM-5) Gene in Escherichia coli by Conjugative CRISPR-Cas9 System

PURPOSE: Plasmid-borne carbapenem resistance gene bla(NDM-5) accelerates the dissemination of carbapenem-resistant Enterobacteriaceae. To efficiently eliminate the bla(NDM-5)-harboring plasmid and sensitize the antibiotic-resistant bacteria to meropenem, we used the CRISPR-Cas9 system for combating...

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Detalles Bibliográficos
Autores principales: Li, Peisi, Wan, Peng, Zhao, Ruonan, Chen, Jin, Li, Xiaoshen, Li, Jie, Xiong, Wenguang, Zeng, Zhenling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004731/
https://www.ncbi.nlm.nih.gov/pubmed/35422639
http://dx.doi.org/10.2147/IDR.S357470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004731/
https://www.ncbi.nlm.nih.gov/pubmed/35422639
http://dx.doi.org/10.2147/IDR.S357470

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