Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3

Mechanistic target of rapamycin complex I (mTORC1) is central to cellular metabolic regulation. mTORC1 phosphorylates a myriad of substrates, but how different substrate specificity is conferred on mTORC1 by different conditions remains poorly defined. Here, we show how loss of the mTORC1 regulator...

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Detalles Bibliográficos
Autores principales: Li, Kristina, Wada, Shogo, Gosis, Bridget S., Thorsheim, Chelsea, Loose, Paige, Arany, Zolt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004751/
https://www.ncbi.nlm.nih.gov/pubmed/35358174
http://dx.doi.org/10.1371/journal.pbio.3001594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004751/
https://www.ncbi.nlm.nih.gov/pubmed/35358174
http://dx.doi.org/10.1371/journal.pbio.3001594

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