A Novel Framework for the Identification of Reference DNA Methylation Libraries for Reference-Based Deconvolution of Cellular Mixtures

Reference-based deconvolution methods use reference libraries of cell-specific DNA methylation (DNAm) measurements as a means toward deconvoluting cell proportions in heterogeneous biospecimens (e.g., whole-blood). As the accuracy of such methods depends highly on the CpG loci comprising the referen...

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Detalles Bibliográficos
Autores principales: Bell-Glenn, Shelby, Thompson, Jeffrey A., Salas, Lucas A., Koestler, Devin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004796/
https://www.ncbi.nlm.nih.gov/pubmed/35419567
http://dx.doi.org/10.3389/fbinf.2022.835591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004796/
https://www.ncbi.nlm.nih.gov/pubmed/35419567
http://dx.doi.org/10.3389/fbinf.2022.835591

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