α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation

BACKGROUND: Oxidative stress underlies metabolic diseases and cognitive impairment; thus, the use of antioxidants may improve brain function in insulin-resistant conditions. We are the first to evaluate the effects of α-lipoic acid (ALA) on redox homeostasis, sphingolipid metabolism, neuroinflammati...

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Detalles Bibliográficos
Autores principales: Maciejczyk, Mateusz, Żebrowska, Ewa, Nesterowicz, Miłosz, Supruniuk, Elżbieta, Choromańska, Barbara, Chabowski, Adrian, Żendzian-Piotrowska, Małgorzata, Zalewska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005076/
https://www.ncbi.nlm.nih.gov/pubmed/35422650
http://dx.doi.org/10.2147/JIR.S358799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005076/
https://www.ncbi.nlm.nih.gov/pubmed/35422650
http://dx.doi.org/10.2147/JIR.S358799

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