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α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation

BACKGROUND: Oxidative stress underlies metabolic diseases and cognitive impairment; thus, the use of antioxidants may improve brain function in insulin-resistant conditions. We are the first to evaluate the effects of α-lipoic acid (ALA) on redox homeostasis, sphingolipid metabolism, neuroinflammati...

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Detalles Bibliográficos
Autores principales:	Maciejczyk, Mateusz, Żebrowska, Ewa, Nesterowicz, Miłosz, Supruniuk, Elżbieta, Choromańska, Barbara, Chabowski, Adrian, Żendzian-Piotrowska, Małgorzata, Zalewska, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005076/ https://www.ncbi.nlm.nih.gov/pubmed/35422650 http://dx.doi.org/10.2147/JIR.S358799

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