Cargando…

α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation

BACKGROUND: Oxidative stress underlies metabolic diseases and cognitive impairment; thus, the use of antioxidants may improve brain function in insulin-resistant conditions. We are the first to evaluate the effects of α-lipoic acid (ALA) on redox homeostasis, sphingolipid metabolism, neuroinflammati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maciejczyk, Mateusz, Żebrowska, Ewa, Nesterowicz, Miłosz, Supruniuk, Elżbieta, Choromańska, Barbara, Chabowski, Adrian, Żendzian-Piotrowska, Małgorzata, Zalewska, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005076/ https://www.ncbi.nlm.nih.gov/pubmed/35422650 http://dx.doi.org/10.2147/JIR.S358799

Ejemplares similares

α-Lipoic Acid Strengthens the Antioxidant Barrier and Reduces Oxidative, Nitrosative, and Glycative Damage, as well as Inhibits Inflammation and Apoptosis in the Hypothalamus but Not in the Cerebral Cortex of Insulin-Resistant Rats
por: Maciejczyk, Mateusz, et al.
Publicado: (2022)

High Protein Diet Induces Oxidative Stress in Rat Cerebral Cortex and Hypothalamus
por: Żebrowska, Ewa, et al.
Publicado: (2019)

Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
por: Nesterowicz, Miłosz, et al.
Publicado: (2022)

Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet-Induced Insulin Resistance
por: Maciejczyk, Mateusz, et al.
Publicado: (2018)

Agomelatine's antiglycoxidative action—In vitro and in silico research and systematic literature review
por: Nesterowicz, Miłosz, et al.
Publicado: (2023)

Blood Profile of Cytokines, Chemokines, Growth Factors, and Redox Biomarkers in Response to Different Protocols of Treadmill Running in Rats
por: Supruniuk, Elżbieta, et al.
Publicado: (2020)

Oxidation, Glycation, and Carbamylation of Salivary Biomolecules in Healthy Children, Adults, and the Elderly: Can Saliva Be Used in the Assessment of Aging?
por: Maciejczyk, Mateusz, et al.
Publicado: (2022)

Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in Patients with Morbid Obesity—A Longitudinal Study
por: Choromańska, Barbara, et al.
Publicado: (2020)

Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative Stress in Morbidly Obese Patients
por: Choromańska, Barbara, et al.
Publicado: (2020)

High-Sugar Diet Disrupts Hypothalamic but Not Cerebral Cortex Redox Homeostasis
por: Żebrowska, Ewa, et al.
Publicado: (2020)

The Impact of High-Fat Diet on Mitochondrial Function, Free Radical Production, and Nitrosative Stress in the Salivary Glands of Wistar Rats
por: Zalewska, Anna, et al.
Publicado: (2019)

The Effect of N-Acetylcysteine on Respiratory Enzymes, ADP/ATP Ratio, Glutathione Metabolism, and Nitrosative Stress in the Salivary Gland Mitochondria of Insulin Resistant Rats
por: Zalewska, Anna, et al.
Publicado: (2020)

Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance
por: Kurek, Krzysztof, et al.
Publicado: (2015)

Antioxidant Barrier and Oxidative Damage to Proteins, Lipids, and DNA/RNA in Adrenal Tumor Patients
por: Choromańska, Barbara, et al.
Publicado: (2021)

Inhibition of Ceramide De Novo Synthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes
por: Kurek, Krzysztof, et al.
Publicado: (2014)

Salivary Xanthine Oxidase as a Potential Biomarker in Stroke Diagnostics
por: Maciejczyk, Mateusz, et al.
Publicado: (2022)

Insulin Resistance and Oxidative Stress in the Brain: What’s New?
por: Maciejczyk, Mateusz, et al.
Publicado: (2019)

Salivary Redox Biomarkers in Insulin Resistance: Preclinical Studies in an Animal Model
por: Maciejczyk, Mateusz, et al.
Publicado: (2021)

Insulin Resistance and Obesity Affect Lipid Profile in the Salivary Glands
por: Matczuk, Jan, et al.
Publicado: (2016)

Effect of N-Acetylcysteine on Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in a Rat Model of Insulin Resistance
por: Żukowski, Piotr, et al.
Publicado: (2018)

A New Insight into Meloxicam: Assessment of Antioxidant and Anti-Glycating Activity in In Vitro Studies
por: Pawlukianiec, Cezary, et al.
Publicado: (2020)

Association Between Salivary Cytokines, Chemokines and Growth Factors and Salivary Gland Function in Children with Chronic Kidney Disease
por: Szulimowska, Julita, et al.
Publicado: (2023)

Does TBC1D4 (AS160) or TBC1D1 Deficiency Affect the Expression of Fatty Acid Handling Proteins in the Adipocytes Differentiated from Human Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Obtained from Subcutaneous and Visceral Fat Depots?
por: Mikłosz, Agnieszka, et al.
Publicado: (2021)

NAC Supplementation of Hyperglycemic Rats Prevents the Development of Insulin Resistance and Improves Antioxidant Status but Only Alleviates General and Salivary Gland Oxidative Stress
por: Zalewska, Anna, et al.
Publicado: (2020)

Antioxidant and Anti-Glycation Potential of H2 Receptor Antagonists—In Vitro Studies and a Systematic Literature Review
por: Biedrzycki, Grzegorz, et al.
Publicado: (2023)

Do Circulating Redox Biomarkers Have Diagnostic Significance in Alcohol-Intoxicated People?
por: Maciejczyk, Mateusz, et al.
Publicado: (2022)

Lack of pronounced changes in the expression of fatty acid handling proteins in adipose tissue and plasma of morbidly obese humans
por: Grzegorczyk, Ewa Anna, et al.
Publicado: (2018)

Metabolic Syndrome is Associated with Ceramide Accumulation in Visceral Adipose Tissue of Women with Morbid Obesity
por: Choromańska, Barbara, et al.
Publicado: (2019)

Pleiotropic Properties of Valsartan: Do They Result from the Antiglycooxidant Activity? Literature Review and In Vitro Study
por: Mil, Kacper Maksymilian, et al.
Publicado: (2021)

The Implication of PGC-1α on Fatty Acid Transport across Plasma and Mitochondrial Membranes in the Insulin Sensitive Tissues
por: Supruniuk, Elżbieta, et al.
Publicado: (2017)

Pyrroloquinoline Quinone Modifies Lipid Profile, but Not Insulin Sensitivity, of Palmitic Acid-Treated L6 Myotubes
por: Supruniuk, Elżbieta, et al.
Publicado: (2020)

Endogenous and Exogenous Antioxidants in Skeletal Muscle Fatigue Development during Exercise
por: Supruniuk, Elżbieta, et al.
Publicado: (2023)

Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients
por: Myśliwiec, Hanna, et al.
Publicado: (2016)

High-Fat Diet Affects Ceramide Content, Disturbs Mitochondrial Redox Balance, and Induces Apoptosis in the Submandibular Glands of Mice
por: Zalewska, Anna, et al.
Publicado: (2019)

Oxidative Modification in the Salivary Glands of High Fat-Diet Induced Insulin Resistant Rats
por: Kołodziej, Urszula, et al.
Publicado: (2017)

Salivary Redox Biomarkers in Different Stages of Dementia Severity
por: Klimiuk, Anna, et al.
Publicado: (2019)

Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis
por: Maciejczyk, Mateusz, et al.
Publicado: (2019)

Eight-Week Consumption of High-Sucrose Diet Has a Pro-Oxidant Effect and Alters the Function of the Salivary Glands of Rats
por: Maciejczyk, Mateusz, et al.
Publicado: (2018)

The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity
por: Choromańska, Barbara, et al.
Publicado: (2020)

A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?
por: Choromańska, Barbara, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ocf4em7nckmivgi11u10q2549q