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Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

In skeletal muscle, transforming growth factor-β (TGF-β) family growth factors, TGF-β1 and myostatin, are involved in atrophy and muscle wasting disorders. Simultaneous interference with their signalling pathways may improve muscle function; however, little is known about their individual and combin...

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Detalles Bibliográficos
Autores principales: Hillege, Michèle MG, Shi, Andi, Galli, Ricardo A, Wu, Gang, Bertolino, Philippe, Hoogaars, Willem MH, Jaspers, Richard T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005187/
https://www.ncbi.nlm.nih.gov/pubmed/35323108
http://dx.doi.org/10.7554/eLife.77610