DYN-1/dynamin regulates microtubule dynamics after axon injury.

Microtubules play essential roles in the regeneration of axons after injury, but precisely how their growth is regulated remains to be resolved. Here, we studied the influence of the C. elegans DYN-1/dynamin GTPase protein on microtubule growth after axon injury. Before injury, loss of DYN-1 had no effect on microtubule dynamics compared to wild-type animals. However, significant increases in microtubule dynamics were observed after axotomy in animals lacking DYN-1. Moreover, a greater proportion of these animals displayed microtubule growth in the retrograde direction compared to wild-type controls. These data establish a role for DYN-1 in regulating microtubule dynamics after injury in C. elegans .