The PARP1 Inhibitor Niraparib Represses DNA Damage Repair and Synergizes with Temozolomide for Antimyeloma Effects

PURPOSE: Poly(ADP-ribose) polymerase 1 (PARP1) is necessary for single-strand break (SSB) repair by sensing DNA breaks and facilitating DNA repair through poly ADP-ribosylation of several DNA-binding and repair proteins. Inhibition of PARP1 results in collapsed DNA replication fork and double-strand...

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Detalles Bibliográficos
Autores principales: Shen, Hong-Yuan, Tang, Hai-Long, Zheng, Yan-Hua, Feng, Juan, Dong, Bao-Xia, Chen, Xie-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005285/
https://www.ncbi.nlm.nih.gov/pubmed/35422863
http://dx.doi.org/10.1155/2022/2800488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005285/
https://www.ncbi.nlm.nih.gov/pubmed/35422863
http://dx.doi.org/10.1155/2022/2800488

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