PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study

Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In this proof-of-principle study, we investigated whether PET mapping of cardiac membrane potential, an indicator of mitochondrial function, could detect an acute cardiotoxic effect of doxorubicin (DOX) in a larg...

Descripción completa

Detalles Bibliográficos
Autores principales: Detmer, Felicitas J., Alpert, Nathaniel M., Moon, Sung-Hyun, Dhaynaut, Maeva, Guerrero, J. Luis, Guehl, Nicolas J., Xing, Fangxu, Brugarolas, Pedro, Shoup, Timothy M., Normandin, Marc D., Pelletier-Galarneau, Matthieu, El Fakhri, Georges, Petibon, Yoann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005533/
https://www.ncbi.nlm.nih.gov/pubmed/35414642
http://dx.doi.org/10.1038/s41598-022-10004-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005533/
https://www.ncbi.nlm.nih.gov/pubmed/35414642
http://dx.doi.org/10.1038/s41598-022-10004-6

Ejemplares similares