Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(®) using terahertz time-domain spectroscopy

We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its [Formula: see text] - cry...

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Autores principales: Ornik, Jan, Heidrich, Lara, Schesny, Robert, Castro-Camus, Enrique, Keck, Cornelia M., Koch, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005722/
https://www.ncbi.nlm.nih.gov/pubmed/35414681
http://dx.doi.org/10.1038/s41598-022-10041-1
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author Ornik, Jan
Heidrich, Lara
Schesny, Robert
Castro-Camus, Enrique
Keck, Cornelia M.
Koch, Martin
author_facet Ornik, Jan
Heidrich, Lara
Schesny, Robert
Castro-Camus, Enrique
Keck, Cornelia M.
Koch, Martin
author_sort Ornik, Jan
collection PubMed
description We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its [Formula: see text] - crystalline form and the amount of A-IM in the smartFilms reduces. Both, [Formula: see text] - and A-IM are preferred over the more common [Formula: see text] - crystalline form, as they exhibit better water solubility, which can increase the oral bioavailability of the drug.
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spelling pubmed-90057222022-04-15 Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(®) using terahertz time-domain spectroscopy Ornik, Jan Heidrich, Lara Schesny, Robert Castro-Camus, Enrique Keck, Cornelia M. Koch, Martin Sci Rep Article We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its [Formula: see text] - crystalline form and the amount of A-IM in the smartFilms reduces. Both, [Formula: see text] - and A-IM are preferred over the more common [Formula: see text] - crystalline form, as they exhibit better water solubility, which can increase the oral bioavailability of the drug. Nature Publishing Group UK 2022-04-12 /pmc/articles/PMC9005722/ /pubmed/35414681 http://dx.doi.org/10.1038/s41598-022-10041-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ornik, Jan
Heidrich, Lara
Schesny, Robert
Castro-Camus, Enrique
Keck, Cornelia M.
Koch, Martin
Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(®) using terahertz time-domain spectroscopy
title Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(®) using terahertz time-domain spectroscopy
title_full Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(®) using terahertz time-domain spectroscopy
title_fullStr Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(®) using terahertz time-domain spectroscopy
title_full_unstemmed Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(®) using terahertz time-domain spectroscopy
title_short Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(®) using terahertz time-domain spectroscopy
title_sort non-destructive crystallinity assessment of indomethacin in tablets made from smartfilms(®) using terahertz time-domain spectroscopy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005722/
https://www.ncbi.nlm.nih.gov/pubmed/35414681
http://dx.doi.org/10.1038/s41598-022-10041-1
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