3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice

Pericytes, mural cells of brain capillaries, maintain the blood-brain barrier (BBB), regulate cerebral blood flow (CBF), and protect neurons against ischemic damage. To further investigate the role of pericytes in ischemia, we induced stroke by 45-min transient middle cerebral artery occlusion (tMCA...

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Detalles Bibliográficos
Autores principales: Wang, Yaoming, Kisler, Kassandra, Nikolakopoulou, Angeliki Maria, Fernandez, Jose A., Griffin, John H., Zlokovic, Berislav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005806/
https://www.ncbi.nlm.nih.gov/pubmed/35431776
http://dx.doi.org/10.3389/fnins.2022.841916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005806/
https://www.ncbi.nlm.nih.gov/pubmed/35431776
http://dx.doi.org/10.3389/fnins.2022.841916

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