Discovery of 2-(4-Acrylamidophenyl)-Quinoline-4-Carboxylic Acid Derivatives as Potent SIRT3 Inhibitors

In discovery of novel SIRT3 inhibitors for the treatment of cancer, a series of 2-(4-acrylamidophenyl)-quinoline-4-carboxylic acid derivatives were designed and synthesized. Among the derived compounds, molecule P6 exhibited SIRT3 inhibitory selectivity with IC(50) value of 7.2 µM over SIRT1 (32.6 µ...

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Detalles Bibliográficos
Autores principales: Hui, Qian, Li, Xueming, Fan, Wenli, Gao, Congying, Zhang, Lin, Qin, Hongyu, Wei, Liuya, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005971/
https://www.ncbi.nlm.nih.gov/pubmed/35433629
http://dx.doi.org/10.3389/fchem.2022.880067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005971/
https://www.ncbi.nlm.nih.gov/pubmed/35433629
http://dx.doi.org/10.3389/fchem.2022.880067

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