The Histone Deacetylase 9 Stroke-Risk Variant Promotes Apoptosis and Inflammation in a Human iPSC-Derived Smooth Muscle Cells Model

A common variant in the Histone Deacetylase 9 (HDAC9) gene is the strongest genetic risk for large-vessel stroke, and HDAC9 offers a novel target for therapeutic modulation. However, the mechanisms linking the HDAC9 variant with increased stroke risk is still unclear due to the lack of relevant mode...

Descripción completa

Detalles Bibliográficos
Autores principales: Granata, Alessandra, Kasioulis, Ioannis, Serrano, Felipe, Cooper, James D., Traylor, Matthew, Sinha, Sanjay, Markus, Hugh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005977/
https://www.ncbi.nlm.nih.gov/pubmed/35433850
http://dx.doi.org/10.3389/fcvm.2022.849664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005977/
https://www.ncbi.nlm.nih.gov/pubmed/35433850
http://dx.doi.org/10.3389/fcvm.2022.849664

Ejemplares similares