Multi-scale mechanistic modelling of the host defence in invasive aspergillosis reveals leucocyte activation and iron acquisition as drivers of infection outcome

Aspergillus species are ubiquitous environmental moulds, with spores inhaled daily by most humans. Immunocompromised hosts can develop an invasive infection resulting in high mortality. There is, therefore, a pressing need for host-centric therapeutics for this infection. To address it, we created a...

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Detalles Bibliográficos
Autores principales: Ribeiro, Henrique AL, Vieira, Luis Sordo, Scindia, Yogesh, Adhikari, Bandita, Wheeler, Matthew, Knapp, Adam, Schroeder, William, Mehrad, Borna, Laubenbacher, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Life Sciences–Mathematics interface
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006013/
https://www.ncbi.nlm.nih.gov/pubmed/35414216
http://dx.doi.org/10.1098/rsif.2021.0806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006013/
https://www.ncbi.nlm.nih.gov/pubmed/35414216
http://dx.doi.org/10.1098/rsif.2021.0806

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