Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ring

Histone deacetylase (HDAC) inhibitors are highly involved in the regulation of many pharmacological responses, which results in anti-inflammatory and anti-cancer effects. In the present work, chemoinformatic analyses were performed to obtain two potent and selective aminotriazoloquinazoline-based HD...

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Detalles Bibliográficos
Autores principales: Moi, Davide, Citarella, Andrea, Bonanni, Davide, Pinzi, Luca, Passarella, Daniele, Silvani, Alessandra, Giannini, Clelia, Rastelli, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006239/
https://www.ncbi.nlm.nih.gov/pubmed/35425078
http://dx.doi.org/10.1039/d2ra01753a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006239/
https://www.ncbi.nlm.nih.gov/pubmed/35425078
http://dx.doi.org/10.1039/d2ra01753a

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