Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2(P95H) mutation

Current strategies to target RNA splicing mutant myeloid cancers proposes targeting the remaining splicing apparatus. This approach has only been modestly sensitizing and is also toxic to non-mutant-bearing wild-type cells. To explore potentially exploitable genetic interactions with spliceosome mut...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Jane Jialu, Chalk, Alistair M., Nikolic, Iva, Simpson, Kaylene J., Smeets, Monique F., Walkley, Carl R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006275/
https://www.ncbi.nlm.nih.gov/pubmed/34464972
http://dx.doi.org/10.1182/bloodadvances.2021004571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006275/
https://www.ncbi.nlm.nih.gov/pubmed/34464972
http://dx.doi.org/10.1182/bloodadvances.2021004571

Ejemplares similares